Sermorelin is a synthetic peptide composed of 28 amino acids and functions as an analog of growth hormone–releasing hormone (GHRH). It promotes immune system activity and supports angiogenesis. In the body, sermorelin stimulates the pituitary gland to release growth hormone, leading to increased IGF-1 levels and a higher number of activated immune cells in circulation. It also triggers calcium-dependent histamine release from mast cells. In addition, sermorelin enhances the secretion of VEGF and chromogranin A, which can contribute to increased proliferation of neuroendocrine tumor cells.
